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Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. The process by which a methyl group is covalently attached to a molecule. The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule. The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule. Any process involved in maintaining the methylation state of a nucleotide sequence. Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression. The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA methylation
Acc: GO:0006306
Aspect: Biological Process
Desc: The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
Proteins in PDR annotated with:
   This term: 98 [Search]
   Term or descendants: 119 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006306 - DNA methylation (interactive image map)
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