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A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle. A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. A cell junction that forms a connection between a cell and the extracellular matrix. A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments. An adherens junction which connects a cell to the extracellular matrix. Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. A cell-substrate adherens junction, also known as a hemiadherens junction (HAJ) that forms one of a pair of junctions in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects). A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cell-substrate adherens junction
Acc: GO:0005924
Aspect: Cellular Component
Desc: An adherens junction which connects a cell to the extracellular matrix.
Synonyms:
  • hemi-adherens junction
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 234 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005924 - cell-substrate adherens junction (interactive image map)
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