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A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals. An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. The apical end of the lateral plasma membrane of epithelial cells.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: tight junction
Acc: GO:0005923
Aspect: Cellular Component
Desc: An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
Synonyms:
  • zonula occludens
Proteins in PDR annotated with:
   This term: 162 [Search]
   Term or descendants: 162 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005923 - tight junction (interactive image map)

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Created and Maintained by: Michael Riffle