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A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits. The polysaccharide-based coating on the inner side of a lysosomal membrane that protects it from digestion by lysosomal enzymes. The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex. A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism. Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome. A lysosome before it has fused with a vesicle or vacuole. The volume enclosed within the lysosomal membrane.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: lysosome
Acc: GO:0005764
Aspect: Cellular Component
Desc: A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
Proteins in PDR annotated with:
   This term: 327 [Search]
   Term or descendants: 408 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005764 - lysosome (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle