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Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: methylenetetrahydrofolate reductase (NADPH) activity
Acc: GO:0004489
Aspect: Molecular Function
Desc: Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
Synonyms:
  • 5,10-methylenetetrahydrofolate reductase (NADPH) activity
  • 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity
  • 5,10-methylenetetrahydrofolic acid reductase activity
  • 5,10-methylenetetrahydrofolate reductase (FADH2) activity
  • 5,10-methylenetetrahydropteroylglutamate reductase activity
  • 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity
  • N5,10-methylenetetrahydrofolate reductase activity
  • GO:0008702
  • MTHFR activity
  • N(5),N(10)-methylenetetrahydrofolate reductase activity
  • N5,N10-methylenetetrahydrofolate reductase activity
  • methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
  • 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity
  • 5-methyltetrahydrofolate:NADP+ oxidoreductase activity
  • methylenetetrahydrofolic acid reductase activity
  • 5,10-CH2-H4folate reductase activity
  • 5-methyltetrahydrofolate:NAD oxidoreductase activity
  • 5,10-methylenetetrahydrofolate reductase (FADH) activity
  • 5-methyltetrahydrofolate:NAD+ oxidoreductase activity
  • methylenetetrahydrofolate reductase activity
  • 1.7.99.5
  • MetF
  • methylenetetrahydrofolate reductase [NAD(P)H]
  • methylenetetrahydrofolate reductase (NADPH2)
  • 5,10-CH(2)-H(4)folate reductase activity
  • methylenetetrahydrofolate reductase (NADPH(2)) activity
  • 5,10-methylenetetrahydrofolate reductase activity
  • 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity
  • methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity
  • 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity
  • N(5,10)-methylenetetrahydrofolate reductase activity
Proteins in PDR annotated with:
   This term: 19 [Search]
   Term or descendants: 19 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004489 - methylenetetrahydrofolate reductase (NADPH) activity (interactive image map)

YRC Informatics Platform - Version 3.0
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