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Catalysis of the elimination of H2S or substituted H2S. Catalysis of the reaction: leukotriene C4 = leukotriene A4 + glutathione. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: leukotriene-C4 synthase activity
Acc: GO:0004464
Aspect: Molecular Function
Desc: Catalysis of the reaction: leukotriene C4 = leukotriene A4 + glutathione.
Synonyms:
  • LTC(4) synthase activity
  • leukotriene C4 synthetase activity
  • leukotriene A4:glutathione S-leukotrienyltransferase activity
  • leukotriene C(4) synthetase activity
  • leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
  • (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)
  • LTC(4) synthetase activity
  • LTC4 synthase activity
  • (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
  • leukotriene A(4):glutathione S-leukotrienyltransferase activity
  • LTC4 synthetase activity
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004464 - leukotriene-C4 synthase activity (interactive image map)
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