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Catalysis of the reaction: isochorismate + H2O = 2,3-dihydro-2,3-dihydroxybenzoate + pyruvate. Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate. Catalysis of the hydrolysis of an ether bond, -O-.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: leukotriene-A4 hydrolase activity
Acc: GO:0004463
Aspect: Molecular Function
Desc: Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
Synonyms:
  • leukotriene A4 hydrolase activity
  • leukotriene A(4) hydrolase activity
  • LTA-4 hydrolase activity
  • LTA4 hydrolase activity
  • LTA4H
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity
Proteins in PDR annotated with:
   This term: 23 [Search]
   Term or descendants: 25 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004463 - leukotriene-A4 hydrolase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle