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Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. null Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. Catalysis of the hydrolysis of a glycerophospholipid.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: phosphoinositide phospholipase C activity
Acc: GO:0004435
Aspect: Molecular Function
Desc: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Synonyms:
  • 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
  • phosphatidylinositol-4,5-bisphosphate hydrolysis
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
  • phosphatidylinositol phospholipase C activity
  • triphosphoinositide phosphodiesterase activity
  • phosphoinositidase C activity
  • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
  • monophosphatidylinositol phosphodiesterase activity
  • PI-PLC activity
Proteins in PDR annotated with:
   This term: 68 [Search]
   Term or descendants: 68 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004435 - phosphoinositide phospholipase C activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle