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Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: GTP cyclohydrolase II activity
Acc: GO:0003935
Aspect: Molecular Function
Desc: Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate.
Synonyms:
  • guanosine triphosphate cyclohydrolase II
  • GTP 7,8-8,9-dihydrolase (diphosphate-forming)
  • GTP-8-formylhydrolase activity
Proteins in PDR annotated with:
   This term: 21 [Search]
   Term or descendants: 21 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003935 - GTP cyclohydrolase II activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle