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An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 2 type immune response. Any process that modulates the frequency, rate, or extent of a T-helper 2 type immune response. Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of T-helper 2 type immune response
Acc: GO:0002829
Aspect: Biological Process
Desc: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 2 type immune response.
Synonyms:
  • down-regulation of T-helper 2 type immune response
  • inhibition of T-helper 2 type immune response
  • downregulation of T-helper 2 type immune response
  • down regulation of T-helper 2 type immune response
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002829 - negative regulation of T-helper 2 type immune response (interactive image map)
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