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The process whereby transitional stage B cells acquire the specialized features of mature B cells in the spleen. The process whereby a nave B cell acquires the specialized features of a mature or memory B cell during an immune response. The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. The process whereby a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: germinal center B cell differentiation
Acc: GO:0002314
Aspect: Biological Process
Desc: The process whereby a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
Synonyms:
  • germinal center B lymphocyte differentiation
  • germinal center B-lymphocyte differentiation
  • germinal center B-cell differentiation
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002314 - germinal center B cell differentiation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle