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The developmental process pertaining to the initial formation of an epithelial tube. The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form. The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals. The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells. The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. The morphogenesis of an embryonic epithelium into a tube-shaped structure. The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: neural tube formation
Acc: GO:0001841
Aspect: Biological Process
Desc: The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
Synonyms:
  • GO:0001679
  • neurulation
  • neural tube morphogenesis
Proteins in PDR annotated with:
   This term: 25 [Search]
   Term or descendants: 100 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001841 - neural tube formation (interactive image map)
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