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The formation of the endoderm during gastrulation. The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate. The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. The commitment of cells to specific cell fates of the endoderm, ectoderm and mesoderm as a part of gastrulation. Any process that mediates the specification of a cell into an endoderm cell. A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that ultimately results in a cell being specified to adopt a definitive endodermal cell fate. Process by which a cell becomes capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Any process that restricts, stops or prevents a cell from specifying into an endoderm cell. The process by which a cell becomes committed to become part of the endoderm.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: endodermal cell fate specification
Acc: GO:0001714
Aspect: Biological Process
Desc: Process by which a cell becomes capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Synonyms:
  • endoderm cell fate specification
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 21 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001714 - endodermal cell fate specification (interactive image map)
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