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Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. A ubiquitin ligase complex found in the ER. A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p. The lipid bilayer surrounding the endoplasmic reticulum. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. A ubiquitin ligase complex found in the cytoplasm.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: Doa10p ubiquitin ligase complex
Acc: GO:0000837
Aspect: Cellular Component
Desc: A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p.
Synonyms:
  • Ssm4p ubiquitin ligase complex
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000837 - Doa10p ubiquitin ligase complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle