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Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure. The disaggregation of a macromolecular complex into its constituent components, carried out at the cellular level. The disaggregation of a protein-RNA complex into its constituent components. Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: spliceosome disassembly
Acc: GO:0000390
Aspect: Biological Process
Desc: Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure.
Synonyms:
  • spliceosome complex disassembly
  • U2-type spliceosome disassembly
  • GO:0000392
  • GO:0000391
  • U12-type spliceosome disassembly
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000390 - spliceosome disassembly (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle