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Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN. Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3. Catalysis of the reaction: 2 H2O + 3-cyano-L-alanine = NH3 + L-aspartate. Catalysis of the reaction: R-CN + H2O = R-COOH + NH3. Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxy-benzoate + NH3. Involved in the bacterial degradation of the herbicide bromoxynil. Catalysis of the reaction: indole-3-acetonitrile (IAN) + 2H2O = indole-3-acetic acid (IAA) + NH3.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nitrilase activity
Acc: GO:0000257
Aspect: Molecular Function
Desc: Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
Synonyms:
  • acetonitrilase activity
  • benzonitrilase activity
  • nitrile aminohydrolase activity
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000257 - nitrilase activity (interactive image map)
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