YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. Catalysis of the reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3NADPH + 3H+ + 3O2 = 4alpha-carboxy, 4beta-methyl-9beta,19-cyclopropylsterol + 3NADP+ + 3H2O. This overall reaction proceeds through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH). Catalysis of the reaction: 4alpha-methyl-delta7-sterol + 3NADPH + 3H+ + 3O2 = 4alpha-carboxy, delta7-sterol + 3NADP+ + 3H2O. This overall reaction proceeds through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH). Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: C-4 methylsterol oxidase activity
Acc: GO:0000254
Aspect: Molecular Function
Desc: Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O.
Synonyms:
  • 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
  • 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)
  • 4-methylsterol oxidase activity
  • methylsterol hydroxylase activity
  • methylsterol monooxygenase activity
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000254 - C-4 methylsterol oxidase activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle