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A ubiquitin ligase complex found in the ER. Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1. A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. A ubiquitin ligase complex found in the cytoplasm.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cytoplasmic ubiquitin ligase complex
Acc: GO:0000153
Aspect: Cellular Component
Desc: A ubiquitin ligase complex found in the cytoplasm.
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 20 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000153 - cytoplasmic ubiquitin ligase complex (interactive image map)
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Created and Maintained by: Michael Riffle