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Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional. The nucleic acid metabolic process by which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. Any cellular metabolic process involving nucleic acids. Any cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination. The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another. A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nucleic acid phosphodiester bond hydrolysis
Acc: GO:0090305
Aspect: Biological Process
Desc: The nucleic acid metabolic process by which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
Synonyms:
  • nucleic acid cleavage
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 292 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0090305 - nucleic acid phosphodiester bond hydrolysis (interactive image map)
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