GO TERM SUMMARY
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Name: |
spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase |
Acc: |
GO:0050983 |
Aspect: |
Biological Process |
Desc: |
The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+. |
Synonyms:
- (4-aminobutyl)lysine synthase activity
- spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase
- spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
- [eIF-5A]-deoxyhypusine synthase activity
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INTERACTIVE GO GRAPH
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