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Catalysis of the reaction: N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: trimethyllysine dioxygenase activity
Acc: GO:0050353
Aspect: Molecular Function
Desc: Catalysis of the reaction: N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2.
Synonyms:
  • 6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
  • trimethyllysine,2-oxoglutarate dioxygenase activity
  • TMLD activity
  • epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity
  • TML-alpha-ketoglutarate dioxygenase activity
  • TML hydroxylase activity
  • trimethyllysine alpha-ketoglutarate dioxygenase activity
  • N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
  • TML dioxygenase activity
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0050353 - trimethyllysine dioxygenase activity (interactive image map)
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