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Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: methylisocitrate lyase activity
Acc: GO:0046421
Aspect: Molecular Function
Desc: Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
Synonyms:
  • MICL
  • (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)
  • 2-methylisocitrate lyase activity
  • (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046421 - methylisocitrate lyase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle