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The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. Any process that stops, prevents or reduces the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation. Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell differentiation. Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation. An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. Any process that stops, prevents or reduces the frequency, rate or extent of T-helper cell differentiation. Any process that modulates the frequency, rate or extent of T-helper cell differentiation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of T-helper 1 cell differentiation
Acc: GO:0045626
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell differentiation.
Synonyms:
  • downregulation of T-helper 1 cell differentiation
  • inhibition of T-helper 1 cell differentiation
  • down regulation of T-helper 1 cell differentiation
  • down-regulation of T-helper 1 cell differentiation
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045626 - negative regulation of T-helper 1 cell differentiation (interactive image map)
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