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Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor. Any process that decreases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. Any process that stops or reduces the activity of a transporter. Any process that modulates the frequency, rate or extent of any biological process, quality or function. Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction. Any process that stops or reduces the activity of an enzyme. Any heritable epigenetic process that stops, prevents or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of molecular function
Acc: GO:0044092
Aspect: Biological Process
Desc: Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 757 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0044092 - negative regulation of molecular function (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle