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The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism. The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA methylation involved in gamete generation
Acc: GO:0043046
Aspect: Biological Process
Desc: The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
Synonyms:
  • de novo DNA methylation
Proteins in PDR annotated with:
   This term: 9 [Search]
   Term or descendants: 9 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043046 - DNA methylation involved in gamete generation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle