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A cascade of processes induced by the detection of DNA damage within a cell. The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. Any cell cycle checkpoint that blocks entry into S phase. Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure. A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. A G1/S transition checkpoint that blocks entry into S phase in response to DNA damage. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: G1/S DNA damage checkpoint
Acc: GO:0031571
Aspect: Biological Process
Desc: A G1/S transition checkpoint that blocks entry into S phase in response to DNA damage.
Synonyms:
  • G1 DNA damage checkpoint
Proteins in PDR annotated with:
   This term: 18 [Search]
   Term or descendants: 23 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031571 - G1/S DNA damage checkpoint (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle