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The process of directing proteins towards a membrane, usually using signals contained within the protein. The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. The process by which a protein translocates through the ER membrane posttranslationally. The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. The directed movement of proteins in a cell, from one side of a membrane to another.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: posttranslational protein targeting to membrane, translocation
Acc: GO:0031204
Aspect: Biological Process
Desc: The process by which a protein translocates through the ER membrane posttranslationally.
Synonyms:
  • posttranslational protein membrane targeting, translocation
  • protein translocation during posttranslational protein targeting to membrane
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031204 - posttranslational protein targeting to membrane, translocation (interactive image map)
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