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The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate. The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord. The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. The regionalization process by which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: smoothened signaling pathway involved in ventral spinal cord patterning
Acc: GO:0021910
Aspect: Biological Process
Desc: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
Synonyms:
  • hh signaling pathway involved in ventral spinal cord patterning
  • smoothened signalling pathway in ventral spinal cord patterning
  • hedgehog signaling pathway involved in ventral spinal cord patterning
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0021910 - smoothened signaling pathway involved in ventral spinal cord patterning (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle