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Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate. Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate. Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3. Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2. Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate. Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate. Catalysis of the reaction: 6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O = 2-formylglutarate + NH. Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate. Catalysis of the reaction: creatinine + H2O = creatine. Catalysis of the reaction: citrazinate + H2O = cis-aconitamide. Catalysis of the reaction: maleimide + H2O = maleamic acid. Catalysis of the reaction: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = H+ + N-formimidoyl-L-glutamate. Catalysis of the reaction: N-formiminoglycine = imidazolone + H2O. Catalysis of the reaction: L-lysine 1,6-lactam + H2O = L-lysine. Catalysis of the reaction: 2 H2O + N-methylhydantoin + ATP = phosphate + N-carbamoylsarcosine + ADP. Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate. Catalysis of the reaction: ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate. Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. Catalysis of the reaction: allantoin + H2O = allantoate. Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine. Catalysis of the reaction: barbiturate + H2O = malonate + urea. Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Acc: GO:0016812
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide.
Proteins in PDR annotated with:
   This term: 25 [Search]
   Term or descendants: 113 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides (interactive image map)
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