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Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H2O = malonate + urea. Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. Catalysis of the reaction: N-formyl-L-methionine + H2O = formate + L-methionine. Catalysis of the reaction: pentanamide + H2O = pentanoate + NH3. Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol. Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH3. Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3. Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3. Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine. Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH3. Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate. Catalysis of the reaction: N-carbamoyl-L-2-amino acid (a 2-ureido carboxylate) + H2O = L-2-amino acid + NH3 + CO2. Catalysis of the reaction: N-acetylphenylethylamine + H2O = phenylethylamine + acetate. Catalysis of the reaction: hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives. Catalysis of the reaction: hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain. Catalysis of the reaction: H2O + L-glutamine (or L-asparagine) = NH3 + L-glutamate (or L-aspartate). Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine. Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate. Catalysis of the reaction: 4-(glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate. Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylamine. Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3. null Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate. Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. Catalysis of the reaction: biotin amide + H2O = biotin + NH3. Catalysis of the reaction: pantothenate + H2O = pantoate + beta-alanine. Catalysis of the reaction: urea-1-carboxylate + H2O = 2 CO2 + 2 NH3. Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine. Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate. Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine. Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline. Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate. Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid. Catalysis of the reaction: formamide + H2O = formate + NH3 + H+. Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate. Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate. Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O = L-aspartate + CO2 + NH3. Catalysis of the reaction: urethane + H2O = ethanol + CO2 + NH3. Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3. Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate. Catalysis of the reaction: (S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine. Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine. Catalysis of the reaction: adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol. Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3. Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the N-deacetylation of GlcNAc-PI to GlcN-PI. Catalysis of the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate. Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate. Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate. Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid. Catalysis of the deamidation of an N-terminal glutamin residue of a protein. Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O = benzyl alcohol + CO2 + glycine. Catalysis of the reaction: H2O + N-acyl-D-aspartate = D-aspartate + carboxylate. Catalysis of the reaction: H2O + N-acyl-D-glutamate = D-glutamate + carboxylate. Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine. Catalysis of the reaction: chitin + H2O = chitosan + acetate. Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. Catalysis of the reaction: L-carnitinamide + H2O = L-carnitine + NH3. Catalysis of the reaction: formamide + H2O = formate + NH3. Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine. Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine. Catalysis of the reaction: N-formyl-L-glutamate + H2O = formate + L-glutamate. Catalysis of the reaction: H2O + N-carbamoylputrescine = NH3 + CO2 + putrescine. Catalysis of the reaction: N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3. Catalysis of the reaction: N1-acetylspermidine + H2O = acetate + spermidine. Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine. Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine. Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid. Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine. Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate. Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3. Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanol-amine + a fatty acid. Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3. Catalysis of the reaction: H2O + N(alpha)-benzyloxycarbonyl-L-leucine = L-leucine + CO2 + benzyl alcohol. Catalysis of the reaction: 2 H2O + 2-(hydroxymethyl)-3-(acetamidomethylene)succinate = CO2 + NH3 + 2-(hydroxymethyl)-4-oxobutanoate + acetate. Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3. Catalysis of the reaction: H2O + N-benzoyl-D-arginine-4-nitroanilide = N-benzoyl-D-arginine + 4-nitroaniline. Catalysis of the reaction: benzoylagmatine + H2O = benzoate + agmatine. Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate. Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate. Catalysis of the reaction: hippurate + H2O = benzoate + glycine. Catalysis of the reaction: gamma-N-formylaminovinylacetate + h@O = gamma-aminovinylacetate+ HCOOH. Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate. Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate. Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine. Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate. Catalysis of the reaction: N-acetyl-beta-alanine + H2O = acetate + beta-alanine. Catalysis of the reaction: N-acetyl-LL2,6-diaminoheptanedioate + H2O = acetate + LL2,6-diaminoheptanedioate. Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate. Catalysis of the reaction: AMP-NH2 (adenosine 5'-monophosphoramidate) = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester. Catalysis of the reaction: indole-3-acetamide (IAM) + H2O = indole-3-acetate (IAA) + NH3. Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine. Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3. Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine. Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH3. Catalysis of the reaction: an anilide + H2O = a carboxylate + aniline. Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine. Catalysis of the reaction: N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine. Catalysis of the reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate. Catalysis of the reaction: N-succinyl-L-glutamate + H2O = succinate + L-glutamate. Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate. Catalysis of the reaction: N-acetyl-L-citrulline + H2O => citrulline + acetate. Catalysis of the reaction: 4-acetamidobutanoyl + H2O = acetate + 4-aminobutanoyl-CoA. Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Acc: GO:0016811
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.
Proteins in PDR annotated with:
   This term: 48 [Search]
   Term or descendants: 629 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle