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Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + succinate. Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH. Catalysis of the hydrolysis of any ester bond. Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH. Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + organic acid. Catalysis of the reaction: S-formylglutathione + H2O = glutathione + formate. Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate. Catalysis of the reaction: S-acylglutathione + H2O = glutathione + a carboxylate. Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH. Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: thiolester hydrolase activity
Acc: GO:0016790
Aspect: Molecular Function
Desc: Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.
Synonyms:
  • thiolesterase activity
Proteins in PDR annotated with:
   This term: 31 [Search]
   Term or descendants: 535 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016790 - thiolester hydrolase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle