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4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + water = 2-methyl-4-amino-5-hydroxymethyl pyrimidine monophosphate + phosphate. Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. Catalysis of the hydrolysis of any acid anhydride. Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate. Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. Catalysis of the reaction: 5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + diphosphate. Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. Catalysis of the reaction: diacylglycerol pyrophosphate + H20 = 3-sn-phosphatidate + phosphate. Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. Catalysis of the reaction: coenzyme A + H20 = 3',5'-ADP + 4'-phosphopantetheine. Catalysis of the reaction: CDP-diacylglycerol + H2O = CMP + phosphatidate. Catalysis of the reaction: diphosphate + H2O = 2 phosphate. Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP. Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate. Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate. Catalysis of the reaction: undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. Catalysis of the reaction: CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate. Catalysis of the reaction: triphosphate + H2O = diphosphate + phosphate. Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide. Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate. Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate. Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end. Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate. Catalysis of the hydrolysis of the diphosphate bond in 5-phosphoribosyl 1-pyrophosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: pyrophosphatase activity
Acc: GO:0016462
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
Proteins in PDR annotated with:
   This term: 27 [Search]
   Term or descendants: 6794 [Refine Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016462 - pyrophosphatase activity (interactive image map)
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