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The process by which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. The process by which a cell becomes committed to become a neural crest cell. The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. The process whereby a relatively unspecialized cell acquires specialized features of a neural crest cell. A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: neural crest cell fate specification
Acc: GO:0014036
Aspect: Biological Process
Desc: The process by which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0014036 - neural crest cell fate specification (interactive image map)
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