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Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains cyclin T and a cyclin-dependent protein kinase catalytic subunit. A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. A positive transcription elongation factor complex b that comprises two subunits; an example is the budding yeast complex containing Svg1p (also called Bur1p) and Bur2p. A positive transcription elongation factor complex b that comprises three subunits; an example is the budding yeast Ctk complex, which consists of Ctk1p, Ctk2p and Ctk3p. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: positive transcription elongation factor complex b
Acc: GO:0008024
Aspect: Cellular Component
Desc: A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains cyclin T and a cyclin-dependent protein kinase catalytic subunit.
Synonyms:
  • P-TEFb
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008024 - positive transcription elongation factor complex b (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle