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The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. The process by which a fluid solution, or part of it, changes into a solid or semisolid mass. The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. The series of events that restore integrity to a damaged tissue, following an injury. A pathway of blood coagulation in which the earlier stages of the cascade are bypassed and the activation of factor X to factor Xa is effected by the combination of factor VIIa + thromboplastin; this second pathway occurs when tissue extracts are present in optimal amounts and is much more rapid than the intrinsic pathway.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: blood coagulation, extrinsic pathway
Acc: GO:0007598
Aspect: Biological Process
Desc: A pathway of blood coagulation in which the earlier stages of the cascade are bypassed and the activation of factor X to factor Xa is effected by the combination of factor VIIa + thromboplastin; this second pathway occurs when tissue extracts are present in optimal amounts and is much more rapid than the intrinsic pathway.
Proteins in PDR annotated with:
   This term: 9 [Search]
   Term or descendants: 9 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007598 - blood coagulation, extrinsic pathway (interactive image map)
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