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Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication. The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. Any process that activates or increases the frequency, rate or extent of initiation of DNA replication. The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. Any cellular metabolic process involving nucleic acids. The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. The reinitiation of DNA replication within a single cell cycle. Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA replication initiation
Acc: GO:0006270
Aspect: Biological Process
Desc: The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
Proteins in PDR annotated with:
   This term: 179 [Search]
   Term or descendants: 236 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006270 - DNA replication initiation (interactive image map)
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