GO TERM SUMMARY
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Name: |
Rab geranylgeranyltransferase activity |
Acc: |
GO:0004663 |
Aspect: |
Molecular Function |
Desc: |
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. |
Synonyms:
- GGTase-II activity
- Rab-protein geranylgeranyltransferase activity
- RabGGTase activity
- geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
- type II protein geranyl-geranyltransferase activity
- GGTaseII activity
- protein geranylgeranyltransferase type II activity
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