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Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: glutathione peroxidase activity
Acc: GO:0004602
Aspect: Molecular Function
Desc: Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.
Synonyms:
  • GSH peroxidase activity
  • reduced glutathione peroxidase activity
  • non-selenium glutathione peroxidase activity
  • selenium-glutathione peroxidase activity
  • glutathione:hydrogen-peroxide oxidoreductase activity
  • GO:0016224
Proteins in PDR annotated with:
   This term: 79 [Search]
   Term or descendants: 79 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004602 - glutathione peroxidase activity (interactive image map)
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