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Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: hydroxymethylglutaryl-CoA reductase (NADPH) activity
Acc: GO:0004420
Aspect: Molecular Function
Desc: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+.
Synonyms:
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
  • HMG-CoA reductase activity
Proteins in PDR annotated with:
   This term: 18 [Search]
   Term or descendants: 18 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle