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Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. Interacting selectively with a DNA sequence that controls the expression of a gene. An activity that results in binding to DNA and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive movement along a single- or double-stranded DNA molecule. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. Interacting selectively and non-covalently with a region in a genome which promotes recombination. Interacting selectively and non-covalently with any nucleic acid. Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). Interacting selectively and non-covalently with damaged DNA. Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule. Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA binding
Acc: GO:0003677
Aspect: Molecular Function
Desc: Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).
Synonyms:
  • plasmid binding
  • microtubule/chromatin interaction
Proteins in PDR annotated with:
   This term: 6993 [Refine Search]
   Term or descendants: 11693 [Refine Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003677 - DNA binding (interactive image map)
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Created and Maintained by: Michael Riffle