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Any process that stops, prevents or reduces the frequency, rate or extent of protein binding. Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. Any process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. The process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway. Any process that modulates the frequency, rate or extent of protein binding. The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Acc: GO:0002032
Aspect: Biological Process
Desc: The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins.
Synonyms:
  • arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway
  • arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway
  • arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002032 - desensitization of G-protein coupled receptor protein signaling pathway by arrestin (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle