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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. Any process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. The process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway. The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site. The process by which a G-protein coupled receptor is taken up into an endocytic vesicle. The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins. The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: desensitization of G-protein coupled receptor protein signaling pathway
Acc: GO:0002029
Aspect: Biological Process
Desc: The process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway.
Synonyms:
  • desensitisation of G-protein coupled receptor protein signalling pathway
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 20 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002029 - desensitization of G-protein coupled receptor protein signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
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