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Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of the reaction: cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O. Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cholesterol 25-hydroxylase activity
Acc: GO:0001567
Aspect: Molecular Function
Desc: Catalysis of the reaction: cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O.
Synonyms:
  • cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity
  • cholesterol 25-monooxygenase activity
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001567 - cholesterol 25-hydroxylase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle