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A cell cycle checkpoint which halts replication in response to nucleotide depletion. The series of molecular events whereby information is sent from one location to another within a cell. The slowing of DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession. A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage. The process whereby a signal is released and/or conveyed from one location to another. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. A cascade of processes induced by the detection of DNA damage within a cell. The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure. A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. A G1/S transition checkpoint that blocks entry into S phase in response to DNA damage.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA damage checkpoint
Acc: GO:0000077
Aspect: Biological Process
Desc: A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
Synonyms:
  • DNA damage response, signal transduction resulting in cell cycle arrest
Proteins in PDR annotated with:
   This term: 97 [Search]
   Term or descendants: 160 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000077 - DNA damage checkpoint (interactive image map)
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