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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Gcd7. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
FAA4
  • lipid particle
  • cytoplasm
  • lipid transport
  • lipid metabolic process
  • N-terminal protein myristoylation
  • long-chain fatty acid-CoA ligase activity
  • FET3
  • plasma membrane
  • high-affinity iron ion transport
  • response to copper ion
  • iron ion transmembrane transporter activity
  • ferroxidase activity
  • GCD1
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • GCD2
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • GCD6
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • GCD7
  • mitochondrion
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • GCN3
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • LOS1
  • mitochondrion
  • nuclear matrix
  • tRNA export from nucleus
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • tRNA binding
  • Ran GTPase binding
  • MET18
  • nucleoplasm
  • telomere maintenance
  • nucleotide-excision repair
  • transcription from RNA polymerase II promoter
  • methionine metabolic process
  • RNA polymerase II transcription factor activity
  • NMD5
  • nucleus
  • cytoplasm
  • protein import into nucleus
  • protein transmembrane transporter activity
  • PRO3
  • cytoplasm
  • proline biosynthetic process
  • pyrroline-5-carboxylate reductase activity
  • SCW4
  • fungal-type cell wall
  • conjugation with cellular fusion
  • glucosidase activity
  • SUI3
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • VAC8
  • fungal-type vacuole
  • vacuole inheritance
  • vacuole fusion, non-autophagic
  • protein targeting to vacuole
  • microautophagy
  • protein binding
  • VMA8
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • vacuolar acidification
  • proton-transporting ATPase activity, rotational mechanism
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 2B complex 5.3237E-14 16 5 5 6292
    guanyl-nucleotide exchange factor complex 1.1147E-12 16 7 5 6292
    eukaryotic translation initiation factor 2 complex 1.8163E-5 16 3 2 6292
    multi-eIF complex 1.6826E-4 16 8 2 6292
    protein complex 3.6103E-3 16 1137 8 6292
    nuclear matrix 5.0798E-3 16 2 1 6292
    nuclear periphery 5.0798E-3 16 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translational initiation 3.8256E-12 16 42 7 6292
    regulation of translational initiation 2.4381E-11 16 11 5 6292
    regulation of translation 2.0658E-7 16 57 5 6292
    posttranscriptional regulation of gene expression 2.918E-7 16 61 5 6292
    regulation of cellular protein metabolic process 5.0607E-7 16 68 5 6292
    regulation of protein metabolic process 7.7519E-7 16 74 5 6292
    translation 1.8398E-5 16 376 7 6292
    cellular macromolecule biosynthetic process 9.3443E-4 16 1187 9 6292
    macromolecule biosynthetic process 9.465E-4 16 1189 9 6292
    cellular biosynthetic process 1.5712E-3 16 1567 10 6292
    gene expression 1.6813E-3 16 1283 9 6292
    biosynthetic process 1.8865E-3 16 1602 10 6292
    cellular protein metabolic process 2.4819E-3 16 1074 8 6292
    protein metabolic process 3.5897E-3 16 1136 8 6292
    regulation of gene expression 3.9309E-3 16 445 5 6292
    regulation of macromolecule biosynthetic process 4.3701E-3 16 456 5 6292
    regulation of cellular biosynthetic process 5.0714E-3 16 472 5 6292
    regulation of biosynthetic process 5.1178E-3 16 473 5 6292
    regulation of macromolecule metabolic process 5.8511E-3 16 488 5 6292
    regulation of primary metabolic process 7.2976E-3 16 514 5 6292
    proline biosynthetic process 7.6106E-3 16 3 1 6292
    regulation of cellular metabolic process 8.7081E-3 16 536 5 6292
    regulation of metabolic process 9.4817E-3 16 547 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation initiation factor activity 1.2832E-13 16 27 7 6292
    translation factor activity, nucleic acid binding 5.4203E-12 16 44 7 6292
    guanyl-nucleotide exchange factor activity 2.5464E-8 16 38 5 6292
    GTPase regulator activity 1.464E-6 16 84 5 6292
    nucleoside-triphosphatase regulator activity 2.7035E-6 16 95 5 6292
    nucleic acid binding 8.9684E-5 16 666 8 6292
    enzyme regulator activity 1.1927E-4 16 207 5 6292
    binding 3.0905E-4 16 1294 10 6292
    pyrroline-5-carboxylate reductase activity 2.5429E-3 16 1 1 6292
    oxidoreductase activity, oxidizing metal ions, oxygen as acceptor 5.0798E-3 16 2 1 6292
    ferroxidase activity 5.0798E-3 16 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle