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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Kap104. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 25 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADR1
  • nucleus
  • regulation of carbohydrate metabolic process
  • transcription
  • peroxisome organization
  • negative regulation of transcription from RNA polymerase II promoter by glucose
  • transcription factor activity
  • AYR1
  • lipid particle
  • cytoplasm
  • mitochondrion
  • endoplasmic reticulum
  • mitochondrial outer membrane
  • phosphatidic acid biosynthetic process
  • acylglycerone-phosphate reductase activity
  • BGL2
  • fungal-type cell wall
  • cellular cell wall organization
  • glucan 1,3-beta-glucosidase activity
  • CBP6
  • mitochondrion
  • translation
  • molecular_function
  • ENP1
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • preribosome, small subunit precursor
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • FAA1
  • lipid particle
  • mitochondrion
  • mitochondrial outer membrane
  • lipid transport
  • lipid metabolic process
  • N-terminal protein myristoylation
  • long-chain fatty acid-CoA ligase activity
  • GAR1
  • box H/ACA snoRNP complex
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • RNA binding
  • GSP1
  • nucleus
  • cytoplasm
  • nucleocytoplasmic transport
  • rRNA processing
  • nucleus organization
  • GTPase activity
  • HEM15
  • mitochondrion
  • mitochondrial inner membrane
  • heme biosynthetic process
  • ferrochelatase activity
  • HRP1
  • nucleus
  • cytoplasm
  • mRNA cleavage factor complex
  • mRNA polyadenylation
  • mRNA cleavage
  • RNA binding
  • KAP104
  • cytosol
  • mRNA-binding (hnRNP) protein import into nucleus
  • protein import into nucleus
  • cell cycle
  • nuclear localization sequence binding
  • KTR3
  • membrane fraction
  • protein amino acid O-linked glycosylation
  • cellular cell wall organization
  • protein amino acid N-linked glycosylation
  • mannosyltransferase activity
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • NAB2
  • nucleus
  • cytoplasm
  • mRNA polyadenylation
  • poly(A)+ mRNA export from nucleus
  • poly(A) RNA binding
  • NDE1
  • mitochondrion
  • NADH oxidation
  • glucose catabolic process to ethanol
  • chronological cell aging
  • NADH dehydrogenase activity
  • OAC1
  • mitochondrion
  • mitochondrial inner membrane
  • sulfate transport
  • oxaloacetate transport
  • secondary active sulfate transmembrane transporter activity
  • oxaloacetate secondary active transmembrane transporter activity
  • PET10
  • lipid particle
  • aerobic respiration
  • molecular_function
  • PET9
  • mitochondrion
  • mitochondrial inner membrane
  • anaerobic respiration
  • mitochondrial transport
  • aerobic respiration
  • ATP transport
  • ADP transport
  • ATP:ADP antiporter activity
  • PSD1
  • mitochondrion
  • mitochondrial inner membrane
  • phosphatidylcholine biosynthetic process
  • phosphatidylserine decarboxylase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • TFG2
  • transcription factor TFIIF complex
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • VMA8
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • vacuolar acidification
  • proton-transporting ATPase activity, rotational mechanism
  • YDL063C
  • nucleus
  • cytoplasm
  • ribosome biogenesis
  • molecular_function
  • YHM2
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial nucleoid
  • tricarboxylic acid transport
  • mitochondrial genome maintenance
  • DNA binding
  • tricarboxylate secondary active transmembrane transporter activity
  • YNL035C
  • nucleus
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrial membrane 5.5655E-5 25 266 7 6292
    envelope 8.1792E-5 25 505 9 6292
    organelle envelope 8.1792E-5 25 505 9 6292
    mitochondrial envelope 1.5276E-4 25 312 7 6292
    organelle membrane 1.6964E-4 25 692 10 6292
    lipid particle 3.3354E-4 25 35 3 6292
    mitochondrial inner membrane 5.1748E-4 25 174 5 6292
    organelle inner membrane 6.8504E-4 25 185 5 6292
    mitochondrial part 1.9387E-3 25 475 7 6292
    outer membrane 4.9189E-3 25 178 4 6292
    organelle outer membrane 4.9189E-3 25 178 4 6292
    box H/ACA snoRNP complex 7.9314E-3 25 2 1 6292
    membrane-bounded organelle 9.1972E-3 25 3771 21 6292
    intracellular membrane-bounded organelle 9.1972E-3 25 3771 21 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mRNA polyadenylation 2.4868E-3 25 19 2 6292
    phosphatidic acid biosynthetic process 3.9733E-3 25 1 1 6292
    phosphatidic acid metabolic process 3.9733E-3 25 1 1 6292
    ADP transport 3.9733E-3 25 1 1 6292
    oxaloacetate transport 3.9733E-3 25 1 1 6292
    RNA polyadenylation 4.6467E-3 25 26 2 6292
    mRNA 3'-end processing 6.5681E-3 25 31 2 6292
    tricarboxylic acid transport 7.9314E-3 25 2 1 6292
    anaerobic respiration 7.9314E-3 25 2 1 6292
    cellular process 9.7232E-3 25 4426 23 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    secondary active transmembrane transporter activity 1.3566E-4 25 26 3 6292
    active transmembrane transporter activity 1.2041E-3 25 121 4 6292
    acylglycerone-phosphate reductase activity 3.9733E-3 25 1 1 6292
    secondary active sulfate transmembrane transporter activity 3.9733E-3 25 1 1 6292
    oxaloacetate secondary active transmembrane transporter activity 3.9733E-3 25 1 1 6292
    oxaloacetate transmembrane transporter activity 3.9733E-3 25 1 1 6292
    tricarboxylate secondary active transmembrane transporter activity 7.9314E-3 25 2 1 6292
    ferrochelatase activity 7.9314E-3 25 2 1 6292
    phosphatidylserine decarboxylase activity 7.9314E-3 25 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle