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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Arp2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 18 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADR1
  • nucleus
  • regulation of carbohydrate metabolic process
  • transcription
  • peroxisome organization
  • negative regulation of transcription from RNA polymerase II promoter by glucose
  • transcription factor activity
  • ARC15
  • mitochondrial envelope
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin cortical patch assembly
  • actin binding
  • structural molecule activity
  • ARC18
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • structural constituent of cytoskeleton
  • ARC19
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin cortical patch assembly
  • structural molecule activity
  • ARC35
  • cytosol
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • microtubule cytoskeleton organization
  • actin cytoskeleton organization
  • structural molecule activity
  • ARC40
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin nucleation
  • actin filament organization
  • structural constituent of cytoskeleton
  • ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • ARP3
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • BNI1
  • polarisome
  • incipient cellular bud site
  • cellular bud tip
  • cellular bud neck
  • mating projection tip
  • actin filament
  • actin cap
  • intracellular mRNA localization
  • bipolar cellular bud site selection
  • regulation of initiation of mating projection growth
  • response to osmotic stress
  • pseudohyphal growth
  • actin filament organization
  • Rho protein signal transduction
  • budding cell bud growth
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • gene conversion at mating-type locus
  • establishment of mitotic spindle orientation
  • filamentous growth
  • actin nucleation
  • regulation of termination of mating projection growth
  • cytoskeletal regulatory protein binding
  • DUR1,2
  • cytoplasm
  • urea metabolic process
  • allantoin catabolic process
  • allophanate hydrolase activity
  • urea carboxylase activity
  • IMH1
  • cytosol
  • Golgi apparatus
  • vesicle-mediated transport
  • Golgi to plasma membrane protein transport
  • molecular_function
  • KAP122
  • cytoplasm
  • nuclear pore
  • protein import into nucleus
  • response to drug
  • regulation of cell size
  • protein transmembrane transporter activity
  • MCM4
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MCM7
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • ATP binding
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MET18
  • nucleoplasm
  • telomere maintenance
  • nucleotide-excision repair
  • transcription from RNA polymerase II promoter
  • methionine metabolic process
  • RNA polymerase II transcription factor activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • TRP3
  • cytoplasm
  • anthranilate synthase complex
  • tryptophan biosynthetic process
  • indole-3-glycerol-phosphate synthase activity
  • anthranilate synthase activity
  • YJR029W
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • DNA-directed DNA polymerase activity
  • RNA-directed DNA polymerase activity
  • RNA binding
  • protein binding
  • ribonuclease activity
  • peptidase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Arp2/3 protein complex 4.1221E-19 18 7 7 6292
    actin cytoskeleton 3.1118E-11 18 85 8 6292
    cytoskeletal part 3.1397E-8 18 201 8 6292
    cytoskeleton 5.5182E-8 18 216 8 6292
    protein complex 7.1619E-7 18 1137 13 6292
    macromolecular complex 5.1941E-5 18 1635 13 6292
    non-membrane-bounded organelle 8.7734E-5 18 959 10 6292
    intracellular non-membrane-bounded organelle 8.7734E-5 18 959 10 6292
    MCM complex 1.6097E-4 18 7 2 6292
    pre-replicative complex 9.059E-4 18 16 2 6292
    intracellular organelle part 2.0665E-3 18 2282 13 6292
    organelle part 2.0665E-3 18 2282 13 6292
    anthranilate synthase complex 5.7138E-3 18 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrion distribution 6.2201E-13 18 29 7 6292
    mitochondrion inheritance 6.2201E-13 18 29 7 6292
    mitochondrion localization 8.1007E-13 18 30 7 6292
    organelle inheritance 1.4923E-11 18 44 7 6292
    organelle localization 3.1118E-11 18 85 8 6292
    actin cytoskeleton organization 3.1788E-10 18 113 8 6292
    actin filament-based process 4.2119E-10 18 117 8 6292
    cytoskeleton organization 9.3181E-8 18 231 8 6292
    mitochondrion organization 1.2742E-7 18 156 7 6292
    actin filament organization 9.7619E-7 18 68 5 6292
    cellular localization 2.371E-6 18 643 10 6292
    actin nucleation 2.3152E-5 18 3 2 6292
    localization 2.0957E-4 18 1060 10 6292
    cellular component organization 2.3977E-4 18 1582 12 6292
    organelle organization 3.5415E-4 18 1127 10 6292
    pre-replicative complex assembly 5.9184E-4 18 13 2 6292
    DNA unwinding involved in replication 6.8931E-4 18 14 2 6292
    actin cortical patch assembly 6.8931E-4 18 14 2 6292
    cortical actin cytoskeleton organization 7.9401E-4 18 15 2 6292
    cortical cytoskeleton organization 7.9401E-4 18 15 2 6292
    DNA geometric change 1.4247E-3 18 20 2 6292
    DNA duplex unwinding 1.4247E-3 18 20 2 6292
    cellular process 1.7601E-3 18 4426 18 6292
    urea metabolic process 2.8608E-3 18 1 1 6292
    cellular component assembly 3.6848E-3 18 385 5 6292
    DNA replication initiation 3.8728E-3 18 33 2 6292
    protein-DNA complex assembly 5.3803E-3 18 39 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of cytoskeleton 1.2584E-5 18 53 4 6292
    cytoskeletal protein binding 1.935E-5 18 59 4 6292
    structural molecule activity 2.3533E-5 18 339 7 6292
    actin binding 2.5324E-5 18 21 3 6292
    ATP binding 3.8332E-5 18 24 3 6292
    adenyl ribonucleotide binding 4.3481E-5 18 25 3 6292
    adenyl nucleotide binding 7.607E-5 18 30 3 6292
    purine nucleoside binding 8.4069E-5 18 31 3 6292
    nucleoside binding 9.26E-5 18 32 3 6292
    ribonucleotide binding 1.9583E-4 18 41 3 6292
    purine ribonucleotide binding 1.9583E-4 18 41 3 6292
    purine nucleotide binding 3.9808E-4 18 52 3 6292
    nucleotide binding 5.7827E-4 18 59 3 6292
    ATP-dependent DNA helicase activity 1.1511E-3 18 18 2 6292
    indole-3-glycerol-phosphate synthase activity 2.8608E-3 18 1 1 6292
    allophanate hydrolase activity 2.8608E-3 18 1 1 6292
    urea carboxylase activity 2.8608E-3 18 1 1 6292
    chromatin binding 3.8728E-3 18 33 2 6292
    DNA helicase activity 4.1079E-3 18 34 2 6292
    binding 5.1118E-3 18 1294 9 6292
    protein binding 5.5221E-3 18 612 6 6292
    anthranilate synthase activity 5.7138E-3 18 2 1 6292
    ATP-dependent helicase activity 8.0666E-3 18 48 2 6292
    purine NTP-dependent helicase activity 8.0666E-3 18 48 2 6292

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