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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Mkk2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 13 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • BCK1
  • intracellular
  • response to acid
  • endoplasmic reticulum unfolded protein response
  • intracellular protein kinase cascade
  • response to nutrient
  • protein amino acid phosphorylation
  • MAP kinase kinase kinase activity
  • BUL1
  • ubiquitin ligase complex
  • plasma membrane
  • mitochondrion inheritance
  • protein polyubiquitination
  • protein monoubiquitination
  • protein binding
  • ubiquitin binding
  • IDH1
  • mitochondrial matrix
  • mitochondrion
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • LYS12
  • mitochondrion
  • lysine biosynthetic process
  • homoisocitrate dehydrogenase activity
  • MKK2
  • intracellular
  • signal transduction
  • protein amino acid phosphorylation
  • MAP kinase kinase activity
  • NPA3
  • cytoplasm
  • biological_process
  • ATPase activity
  • PRB1
  • fungal-type vacuole lumen
  • fungal-type vacuole
  • cellular response to starvation
  • sporulation resulting in formation of a cellular spore
  • vacuolar protein catabolic process
  • serine-type endopeptidase activity
  • RGD1
  • cellular bud
  • actin cortical patch
  • response to acid
  • osmosensory signaling pathway
  • Rho GTPase activator activity
  • RNQ1
  • cytosol
  • biological_process
  • molecular_function
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RVB1
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • chromatin remodeling complex
  • chromatin remodeling
  • regulation of transcription from RNA polymerase II promoter
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome regulatory particle 9.7297E-4 13 23 2 6292
    proteasome accessory complex 9.7297E-4 13 23 2 6292
    proteasome complex 4.2134E-3 13 48 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    response to acid 2.145E-4 13 11 2 6292
    mitochondrion distribution 1.5505E-3 13 29 2 6292
    mitochondrion inheritance 1.5505E-3 13 29 2 6292
    mitochondrion localization 1.6593E-3 13 30 2 6292
    response to extracellular stimulus 2.6567E-3 13 38 2 6292
    response to nutrient levels 2.6567E-3 13 38 2 6292
    response to external stimulus 2.6567E-3 13 38 2 6292
    organelle inheritance 3.5501E-3 13 44 2 6292
    cellular protein catabolic process 4.6147E-3 13 171 3 6292
    protein catabolic process 6.1077E-3 13 189 3 6292
    cellular catabolic process 8.2693E-3 13 415 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    homoisocitrate dehydrogenase activity 2.0661E-3 13 1 1 6292
    isocitrate dehydrogenase (NAD+) activity 4.1283E-3 13 2 1 6292
    endopeptidase activity 5.308E-3 13 54 2 6292
    MAP kinase kinase activity 8.2408E-3 13 4 1 6292
    serine-type endopeptidase activity 8.2408E-3 13 4 1 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 9.5347E-3 13 73 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle