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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Cdc55. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CCT2
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CCT3
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CCT5
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CCT6
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CDC55
  • nucleus
  • cellular bud tip
  • cellular bud neck
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • negative regulation of exit from mitosis
  • protein amino acid dephosphorylation
  • pseudohyphal growth
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • protein phosphatase type 2A regulator activity
  • PPH21
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
  • PPH22
  • condensed nuclear chromosome, centromeric region
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
  • TCP1
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • TPD3
  • nucleus
  • cellular bud tip
  • cytoplasm
  • cellular bud neck
  • spindle pole body
  • mating projection tip
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • YHR033W
  • cytoplasm
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chaperonin-containing T-complex 2.4212E-12 10 12 5 6292
    protein phosphatase type 2A complex 4.8208E-11 10 6 4 6292
    protein serine/threonine phosphatase complex 7.585E-9 10 17 4 6292
    cytoskeleton 2.8602E-7 10 216 6 6292
    cytosolic part 5.8882E-7 10 122 5 6292
    protein complex 1.6785E-6 10 1137 9 6292
    cytosol 3.7818E-5 10 284 5 6292
    macromolecular complex 4.0767E-5 10 1635 9 6292
    non-membrane-bounded organelle 1.4707E-4 10 959 7 6292
    intracellular non-membrane-bounded organelle 1.4707E-4 10 959 7 6292
    cellular bud tip 3.4634E-3 10 57 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoskeleton organization 1.0077E-12 10 231 9 6292
    mitotic cell cycle spindle assembly checkpoint 1.9016E-8 10 21 4 6292
    negative regulation of mitotic metaphase/anaphase transition 1.9016E-8 10 21 4 6292
    spindle assembly checkpoint 1.9016E-8 10 21 4 6292
    negative regulation of nuclear division 1.9016E-8 10 21 4 6292
    negative regulation of mitosis 1.9016E-8 10 21 4 6292
    negative regulation of cell cycle 2.3224E-8 10 22 4 6292
    regulation of mitotic metaphase/anaphase transition 4.0069E-8 10 25 4 6292
    mitotic cell cycle spindle checkpoint 4.0069E-8 10 25 4 6292
    spindle checkpoint 4.0069E-8 10 25 4 6292
    protein folding 6.1763E-8 10 78 5 6292
    mitotic cell cycle checkpoint 6.4706E-8 10 28 4 6292
    protein amino acid dephosphorylation 6.4706E-8 10 28 4 6292
    negative regulation of cellular component organization 7.5002E-8 10 29 4 6292
    regulation of nuclear division 7.5002E-8 10 29 4 6292
    negative regulation of organelle organization 7.5002E-8 10 29 4 6292
    regulation of mitosis 7.5002E-8 10 29 4 6292
    negative regulation of cell cycle process 1.133E-7 10 32 4 6292
    budding cell bud growth 1.4589E-7 10 34 4 6292
    mitotic metaphase/anaphase transition 2.0728E-7 10 37 4 6292
    dephosphorylation 2.8617E-7 10 40 4 6292
    regulation of organelle organization 8.3997E-7 10 52 4 6292
    cellular protein metabolic process 1.0138E-6 10 1074 9 6292
    cell cycle checkpoint 1.3103E-6 10 58 4 6292
    organelle organization 1.5524E-6 10 1127 9 6292
    protein metabolic process 1.6655E-6 10 1136 9 6292
    actin filament organization 2.4959E-6 10 68 4 6292
    regulation of mitotic cell cycle 2.971E-6 10 71 4 6292
    regulation of cellular component organization 3.7051E-6 10 75 4 6292
    regulation of cell cycle process 5.0482E-6 10 81 4 6292
    asexual reproduction 7.6996E-6 10 90 4 6292
    cell budding 7.6996E-6 10 90 4 6292
    mitosis 1.3707E-5 10 104 4 6292
    nuclear division 1.4786E-5 10 106 4 6292
    organelle fission 1.9061E-5 10 113 4 6292
    actin cytoskeleton organization 1.9061E-5 10 113 4 6292
    actin filament-based process 2.1879E-5 10 117 4 6292
    cellular component organization 3.0582E-5 10 1582 9 6292
    M phase of mitotic cell cycle 3.1217E-5 10 128 4 6292
    regulation of cell cycle 3.4206E-5 10 131 4 6292
    growth 5.102E-5 10 145 4 6292
    cell division 5.102E-5 10 145 4 6292
    signal transduction 2.3254E-4 10 214 4 6292
    signal transmission 2.4538E-4 10 217 4 6292
    signaling process 2.4538E-4 10 217 4 6292
    reproduction of a single-celled organism 2.4538E-4 10 217 4 6292
    phosphorus metabolic process 3.0194E-4 10 229 4 6292
    phosphate metabolic process 3.0194E-4 10 229 4 6292
    negative regulation of cellular process 4.2283E-4 10 250 4 6292
    signaling 4.3593E-4 10 252 4 6292
    negative regulation of biological process 4.4258E-4 10 253 4 6292
    mitotic cell cycle 4.5611E-4 10 255 4 6292
    cellular macromolecule metabolic process 7.3309E-4 10 2285 9 6292
    M phase 7.8411E-4 10 294 4 6292
    macromolecule metabolic process 9.2762E-4 10 2349 9 6292
    reproduction 1.1852E-3 10 328 4 6292
    post-translational protein modification 1.628E-3 10 357 4 6292
    cell cycle phase 1.975E-3 10 376 4 6292
    translation 1.975E-3 10 376 4 6292
    G1/S transition of mitotic cell cycle 2.6741E-3 10 50 2 6292
    cell cycle process 5.2211E-3 10 490 4 6292
    primary metabolic process 5.4001E-3 10 2896 9 6292
    protein modification process 5.5762E-3 10 499 4 6292
    negative regulation of exit from mitosis 6.3436E-3 10 4 1 6292
    cell cycle 6.6952E-3 10 525 4 6292
    cellular metabolic process 7.9165E-3 10 3033 9 6292
    macromolecule modification 8.9239E-3 10 569 4 6292
    interphase of mitotic cell cycle 9.7663E-3 10 97 2 6292
    interphase 9.7663E-3 10 97 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    unfolded protein binding 1.7604E-8 10 61 5 6292
    protein serine/threonine phosphatase activity 7.3756E-6 10 26 3 6292
    phosphoprotein phosphatase activity 3.4514E-5 10 43 3 6292
    phosphatase activity 2.8569E-4 10 87 3 6292
    phosphoric ester hydrolase activity 4.57E-4 10 102 3 6292
    binding 1.0216E-3 10 1294 7 6292
    protein binding 1.4242E-3 10 612 5 6292
    metal ion binding 3.228E-3 10 55 2 6292
    ion binding 3.3447E-3 10 56 2 6292
    cation binding 3.3447E-3 10 56 2 6292
    protein phosphatase type 2A regulator activity 6.3436E-3 10 4 1 6292

    YRC Informatics Platform - Version 3.0
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