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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Cka1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 30 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CKA1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • CKB1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 regulator activity
  • CKB2
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 regulator activity
  • DBP2
  • nucleus
  • cytoplasm
  • mitochondrion
  • nuclear outer membrane
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • RNA helicase activity
  • EGD1
  • nascent polypeptide-associated complex
  • 'de novo' cotranslational protein folding
  • unfolded protein binding
  • ENP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • FPR3
  • nucleolus
  • meiotic recombination checkpoint
  • peptidyl-prolyl cis-trans isomerase activity
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • HHT1, HHT2
  • nucleus
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • nucleosome
  • mitotic cell cycle spindle assembly checkpoint
  • DNA repair
  • negative regulation of biosynthetic process
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • response to DNA damage stimulus
  • aging
  • DNA packaging
  • nucleosome assembly
  • negative regulation of transposition, RNA-mediated
  • chromosome organization
  • negative regulation of transcription
  • negative regulation of transposition
  • regulation of transposition
  • regulation of transposition, RNA-mediated
  • DNA binding
  • HOT1
  • nuclear chromosome
  • hyperosmotic response
  • regulation of transcription from RNA polymerase II promoter
  • specific RNA polymerase II transcription factor activity
  • HTA1
  • nuclear nucleosome
  • DNA repair
  • chromatin assembly or disassembly
  • DNA binding
  • HTB2
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • DNA binding
  • KRE33
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • KRI1
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • MGM101
  • mitochondrial chromosome
  • mitochondrion
  • mitochondrial nucleoid
  • DNA repair
  • mitochondrial genome maintenance
  • DNA binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • NOP56
  • box C/D snoRNP complex
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PDI1
  • endoplasmic reticulum lumen
  • protein folding
  • protein disulfide isomerase activity
  • protein disulfide oxidoreductase activity
  • POB3
  • nucleus
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • chromatin remodeling
  • DNA-dependent DNA replication
  • chromatin assembly or disassembly
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • chromatin binding
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • PWP1
  • nucleus
  • cytoplasm
  • nucleolus
  • rRNA processing
  • molecular_function
  • SPT16
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • transcription elongation factor complex
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • transcription elongation regulator activity
  • RNA polymerase II transcription elongation factor activity
  • SSF1
  • nucleolus
  • conjugation with cellular fusion
  • regulation of cell size
  • ribosomal large subunit assembly
  • rRNA binding
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • YER084W

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.3965E-16 30 211 16 6292
    nuclear lumen 7.5255E-14 30 453 18 6292
    non-membrane-bounded organelle 8.9374E-14 30 959 23 6292
    intracellular non-membrane-bounded organelle 8.9374E-14 30 959 23 6292
    organelle lumen 2.1674E-13 30 660 20 6292
    intracellular organelle lumen 2.1674E-13 30 660 20 6292
    membrane-enclosed lumen 6.6842E-13 30 700 20 6292
    nuclear part 1.9268E-12 30 1103 23 6292
    intracellular organelle part 1.5272E-7 30 2282 25 6292
    organelle part 1.5272E-7 30 2282 25 6292
    protein kinase CK2 complex 3.901E-7 30 4 3 6292
    nucleus 8.0864E-7 30 2041 23 6292
    protein-DNA complex 6.1184E-6 30 57 5 6292
    nuclear chromatin 2.0811E-5 30 73 5 6292
    nuclear nucleosome 2.0909E-5 30 12 3 6292
    nucleosome 2.0909E-5 30 12 3 6292
    FACT complex 2.1979E-5 30 2 2 6292
    chromatin 2.7013E-5 30 77 5 6292
    nuclear replication fork 1.0559E-4 30 20 3 6292
    chromosome 2.3612E-4 30 274 7 6292
    alpha DNA polymerase:primase complex 4.5476E-4 30 7 2 6292
    nuclear chromosome 6.0586E-4 30 228 6 6292
    nuclear outer membrane 6.7985E-4 30 86 4 6292
    replication fork 9.9067E-4 30 42 3 6292
    nuclear membrane 1.0696E-3 30 97 4 6292
    nuclear chromosome part 1.8355E-3 30 190 5 6292
    nuclear envelope 2.2504E-3 30 199 5 6292
    replisome 3.2069E-3 30 18 2 6292
    nuclear replisome 3.2069E-3 30 18 2 6292
    chromosomal part 4.788E-3 30 237 5 6292
    transcription elongation factor complex 5.2251E-3 30 23 2 6292
    membrane-bounded organelle 5.4555E-3 30 3771 25 6292
    intracellular membrane-bounded organelle 5.4555E-3 30 3771 25 6292
    intracellular part 6.3373E-3 30 4938 29 6292
    intracellular 7.6883E-3 30 4975 29 6292
    mitochondrial chromosome 9.5139E-3 30 2 1 6292
    cytoplasmic chromosome 9.5139E-3 30 2 1 6292
    box C/D snoRNP complex 9.5139E-3 30 2 1 6292
    replication fork protection complex 9.5139E-3 30 2 1 6292
    outer membrane 9.5496E-3 30 178 4 6292
    organelle outer membrane 9.5496E-3 30 178 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.1634E-10 30 346 14 6292
    ribonucleoprotein complex biogenesis 3.2902E-10 30 374 14 6292
    cellular component biogenesis 1.3174E-9 30 694 17 6292
    rRNA metabolic process 8.2069E-9 30 137 9 6292
    rRNA processing 9.4694E-8 30 128 8 6292
    RNA metabolic process 1.7468E-7 30 954 17 6292
    nucleic acid metabolic process 2.7575E-7 30 1415 20 6292
    regulation of transcription from RNA polymerase I promoter 3.901E-7 30 4 3 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.5836E-6 30 1566 20 6292
    ncRNA metabolic process 1.8525E-6 30 257 9 6292
    regulation of transcription from RNA polymerase III promoter 3.3805E-6 30 7 3 6292
    ncRNA processing 4.9899E-6 30 215 8 6292
    flocculation via cell wall protein-carbohydrate interaction 1.1479E-5 30 10 3 6292
    cellular nitrogen compound metabolic process 1.2348E-5 30 1770 20 6292
    nitrogen compound metabolic process 1.4994E-5 30 1791 20 6292
    flocculation 1.5733E-5 30 11 3 6292
    chromatin assembly or disassembly 1.9847E-5 30 35 4 6292
    cellular macromolecule metabolic process 3.9457E-5 30 2285 22 6292
    gene expression 6.4098E-5 30 1283 16 6292
    macromolecule metabolic process 6.4516E-5 30 2349 22 6292
    RNA processing 2.9642E-4 30 380 8 6292
    G2/M transition of mitotic cell cycle 3.2878E-4 30 29 3 6292
    cellular process 3.4809E-4 30 4426 29 6292
    transcription from RNA polymerase I promoter 3.6414E-4 30 30 3 6292
    response to DNA damage stimulus 7.2721E-4 30 236 6 6292
    transcription from RNA polymerase III promoter 7.3741E-4 30 38 3 6292
    G1/S transition of mitotic cell cycle 1.6485E-3 30 50 3 6292
    cellular response to stress 2.1168E-3 30 290 6 6292
    primary metabolic process 2.2099E-3 30 2896 22 6292
    transcription 3.4334E-3 30 552 8 6292
    ribosomal large subunit biogenesis 3.5011E-3 30 65 3 6292
    multi-organism process 4.4282E-3 30 143 4 6292
    cellular metabolic process 4.5579E-3 30 3033 22 6292
    negative regulation of transposition, RNA-mediated 4.768E-3 30 1 1 6292
    regulation of transposition, RNA-mediated 4.768E-3 30 1 1 6292
    establishment of ribosome localization 6.6528E-3 30 26 2 6292
    ribosome localization 6.6528E-3 30 26 2 6292
    ribosomal subunit export from nucleus 6.6528E-3 30 26 2 6292
    response to stress 7.5525E-3 30 497 7 6292
    cellular response to stimulus 7.9299E-3 30 379 6 6292
    transcription, DNA-dependent 8.0557E-3 30 503 7 6292
    metabolic process 8.3631E-3 30 3157 22 6292
    regulation of transcription 8.4405E-3 30 384 6 6292
    RNA biosynthetic process 8.494E-3 30 508 7 6292
    meiotic prophase I 9.5139E-3 30 2 1 6292
    meiotic cell cycle checkpoint 9.5139E-3 30 2 1 6292
    prophase 9.5139E-3 30 2 1 6292
    meiotic recombination checkpoint 9.5139E-3 30 2 1 6292
    negative regulation of cell cycle process 9.975E-3 30 32 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein kinase CK2 regulator activity 2.1979E-5 30 2 2 6292
    nucleic acid binding 2.9166E-3 30 666 9 6292
    binding 3.9329E-3 30 1294 13 6292
    obsolete_molecular_function 4.1461E-3 30 69 3 6292
    ribosomal large subunit binding 4.768E-3 30 1 1 6292
    protein kinase CK2 activity 9.5139E-3 30 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle